Antimutagenic effect of elastatinal, a protease inhibitor from actinomycetes.
نویسندگان
چکیده
منابع مشابه
Effect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor
Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...
متن کاملEffect of protease inhibitors of actinomycetes on lysosomal peptide-hydrolases from swine liver.
small pieces, homogenized with two volumes of 50mMTris buffer (pH 7.4) containing 0.25 Msucrose and 1 mMEDTA, and centrifuged at 700g for 10minutes. After removal of the precipitate (nuclear-debris), the supernatant was further centrifuged at 7,000g for 60minutes. To the resulting sediment (lysosomal-mitochondrial pellet) was added 200ml of cold acetone, and the suspension was stirred for an ho...
متن کاملThe structure of elastatinal, an elastase inhibitor of microbial origin.
Elastatinal1) is an elastase inhibitor which was found in culture filtrates of various species of actinomycetes. In this communication, its structural elucidation is reported. The properties of elastatinal have already been described in a previous papery. It has the molecular formula C21H36N8O7. The IR [1725. 1655 (broad) and 1550 (broad) cm-1] and UV [2 0.1N HCl max: 275 nm (E 1% 1cm, 1.5)] sp...
متن کاملAntimutagenic Effect of Resveratrol
LANGOVÁ M., POLÍVKOVÁ Z., ŠMERÁK P., BÁRTOVÁ J., BÁRTA I. (2005): Antimutagenic effect of resveratrol. Czech J. Food Sci., 23: 202–208. Evidence exist from population-based and laboratory studies that some phytochemicals have protective effects against tumors or other diseases and reveal antimutagenic activity. We studied the protective effect of the plant phytoallexin resveratrol on the mutage...
متن کاملEffect of Biomolecular Conformation on Docking Simulation: A Case Study on a Potent HIV-1 Protease Inhibitor
Human immunodeficiency virus infection / acquired immunodeficiency syndrome (HIV/AIDS) is a disease pertained to the human immune system. Given its crucial role in viral replication, HIV-1 protease (HIV-1 PR) is a prime therapeutic target in AIDS therapy. In this regard, the dynamic aspects of ligand-enzyme interactions may indicate an important role of conformational variability in HIV-1 PR in...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the Japan Academy, Series B
سال: 1977
ISSN: 0386-2208,1349-2896
DOI: 10.2183/pjab.53.30